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27 Live, 1012 Church St.,  presents “Unplugged” with Paul McComas and Maya Kuper backed up by guitarist/flutist Mike Holden and drummer Justin Marsh at 7 p.m. on Oct. 21.

This is a 75-minute program of scenes and songs to combat rape, despair, depression and suicide, adapted from Mr. McComas’ 2002 novel of the same name.

“Unplugged” is the story of troubled 27-year-old alt-rocker and rape survivor Dayna Clay, played and sung by Ms. Kuper, including her solitary journey into the wilderness of the South Dakota Badlands and her subsequent struggle to recover from depression, come to terms with her traumatic childhood, secure a hard-won inner peace and reach out to others who themselves are in crisis.

The duo is touring the nation to raise funds and awareness for the Rape, Abuse & Incest National Network (RAINN).

Mr. McComas, who has worked with RAINN for 12 years, said “The show alternates songs and scenes … [with] a combination of drama and original music of five genres: rock, folk, pop, Western and Native American. Maya and I enjoy exploring the nexus between the arts and social outreach.”

Patrick J. Kennedy is slated to speak at the event, which will also benefit the former Congressman’s One Mind, a non-profit co-founded with mental-health advocates Garen and Shari Staglin. The organization works to develop better diagnostics and treatments for diseases and injuries of the brain and believes in combating the stigma around mental illness.

Of the $10 ticket price, $5 will go to the organizations; the other $5 serves as a food-and-drink credit for attendees.